Glyceraldehyde-3-phosphate dehydrogenase (Protein name
), G3P_PIG from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Related Databases
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Gene name:
GAPDH(GAPD);
Protein name:
Glyceraldehyde-3-phosphate dehydrogenase(GAPDH);
Alternative:
2.6.99.-;Peptidyl-cysteine S-nitrosylase GAPDH);
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation.
Function:
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.
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Precision
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Recovery
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Linearity
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References
1.
"Sus scrofa glyceraldehyde-3-phosphate dehydrogenase, genomic and cDNA sequences." Behdjani R.
,
Silversides D.W.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.
"Evaluation and characterization of a porcine small intestine cDNA library." Winteroe A.K.
,
Fredholm M.
Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-126